Insulin-like growth factor binding protein-3 (IGFBP-3): Novel ligands mediate unexpected functions
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چکیده
منابع مشابه
polymorphism of insulin-like growth factor binding protein-3 (igfbp-3) gene associated with growth traits in cyprinus carpio
the genetic polymorphism of insulin-like growth factor binding protein ( igfbp-3 ) and its association with the growth traits namely condition factor, body weight, and total length were investigated in common carp cyprinus carpio using pcr- single strand conformation polymorphism (sscp) technique. caudal fin clips from 120 c. carpio , aging 5 months, were used in this study and a 330 bp dna fra...
متن کاملEvidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation.
IGF-binding protein (IGFBP)-3 is a metabolic regulator that has been shown to inhibit insulin-stimulated glucose uptake in murine models. This finding contrasts with epidemiological evidence of decreased serum IGFBP-3 in patients with type 2 diabetes. The purpose of this study was to clarify the role of IGFBP-3 in metabolism. Four-week-old male IGFBP-3(-/-) and control mice were subjected to a ...
متن کاملThe insulin-like growth factor-binding protein (IGFBP) superfamily.
Over the last decade, the concept of an IGFBP family has been well accepted, based on structural similarities and on functional abilities to bind IGFs with high affinities. The existence of other potential IGFBPs was left open. The discovery of proteins with N-terminal domains bearing striking structural similarities to the N terminus of the IGFBPs, and with reduced, but demonstrable, affinity ...
متن کاملUsefullness of Serum Insulin-Like Growth Factor (IGF-1) and Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) for Colorectal Cancer Diagnosis
Insulin-like growth factor (IGF-1) is a potent mitogen and an anti-apoptotic agent which is regulated by insulin-like growth factor binding protein-3 (IGFBP-3). IGFBP-3 carries IGF-1 through the bloodstream to the target tissues and protects it from proteolytic degradation. IGFBP-3 reduces tumorigenic potential of colon cancer cells in vitro. IGFBP3 may inhibit target cells directly. In the pre...
متن کاملVertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3.
BACKGROUND A recent report suggested that men with vertex balding have higher levels of plasma insulin-like growth factor 1 (IGF-1). The association of its major carrier protein, insulin-like growth factor binding protein 3 (IGFBP-3), with male pattern hair loss has not been examined. OBJECTIVE We evaluated the relations of plasma concentrations of IGF-1 and IGFBP-3 with vertex balding in mid...
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ژورنال
عنوان ژورنال: Journal of Cell Communication and Signaling
سال: 2013
ISSN: 1873-9601,1873-961X
DOI: 10.1007/s12079-013-0203-9